2019-05-08 09:46:512025-05-14 11:52:27
description
low affinity potassium channel [[protein|KtrC]]-[[protein|KtrD]], peripheric membrane component
glutamate-controlled potassium channel [[protein|KtrC]]-[[protein|KtrD]], peripheric membrane component
locus
BSU14510
BSU_14510
product
low affinity potassium channel [[protein|KtrC]]-[[protein|KtrD]], peripheric membrane component
glutamate-controlled potassium channel [[protein|KtrC]]-[[protein|KtrD]], peripheric membrane component
outlinks
bsu
BSU14510
BSU_14510
The protein
Kinetic information
the [[protein|KtrC]]-[[protein|KtrD ]]channel has a low affinity for potassium,this is determined by [[protein|KtrD]] [pubmed|30753894]
the [[protein|KtrC]]-[[protein|KtrD ]]channel has a low affinity for potassium, this is determined by [[protein|KtrD]] [pubmed|30753894]
the affinity of [[protein|KtrC]]-[[protein|KtrD]] for potassium is strongly increased in the presence of glutamate (from 0.278 mM to 0.17 mM) [pubmed|32253343]
The protein
[SW|Domains]
contains a [SW|RCK_N domain] at the N-terminus (according to [http://www.uniprot.org/uniprot/?query=RCK+N-terminal+domain&sort=score UniProt])
contains a c-di-AMP-binding [SW|RCK_C domain] at the C-terminus (according to [http://www.uniprot.org/uniprot/?query=RCK+C-terminal+domain&sort=score UniProt]) [Pubmed|23671116]
contains a [SW|RCK_N domain] at the N-terminus (aa 4-126)(according to [http://www.uniprot.org/uniprot/?query=RCK+N-terminal+domain&sort=score UniProt])
contains a c-di-AMP-binding [SW|RCK_C domain] at the C-terminus (aa 135-219) (according to [http://www.uniprot.org/uniprot/?query=RCK+C-terminal+domain&sort=score UniProt]) [Pubmed|23671116]
The protein
Effectors of protein activity
binds ADP and ATP [pubmed|30753894]
the protein binds c-di-AMP, KD = 30 nM [Pubmed|30753894]
binds ADP and ATP [pubmed|30753894]
the protein binds c-di-AMP, KD = 30 nM, this results in inhibition of potassium uptake [Pubmed|30753894]
the affinity of [[protein|KtrC]]-[[protein|KtrD]] for potassium is strongly increased in the presence of glutamate [pubmed|32253343]
References
Reviews
References
Original publications
Labs working on this gene/protein
[SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]
labs
[SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi Homepage]
[SW|Inga Hänelt], Frankfurt, Germany [https://www.biochem.uni-frankfurt.de/index.php?id=298 Homepage]
[SW|João H Morais-Cabral], University of Porto, Portugal [https://www.i3s.up.pt/research-group?x=47 Homepage]
[SW|Jörg Stülke], University of Göttingen, Germany [http://genmibio.uni-goettingen.de Homepage]